Iboga treatment for HIV/AIDS
Iboga is often chemically extracted to isolate the Iboga alkaloid called Ibogaine. Unfortunately, Iboga contains 12 active alkaloids that have been shown to host a variety of medical benefits. A recent study shows the antiviral benefits of another of Iboga’s alkaloid congeners – 18-MC, or 18-methoxycoronaridine.
In the study done in Brazil by Dr. Edinete Silva et al, 18-MC is shown to exhibit in vitro leishmanicidal properties. 18-MC is described as inhibiting HIV-1 infection in human peripheral blood mononuclear cells and monocyte-derived macrophages. 18-MC was also found to inhibit the replication of primary isolates of HIV-1 in the blood. 18-MC was described at inhibiting HIV-1 enzyme transcriptase which partially explains its antiretroviral activity.
This study is very promising as 18-MC provides a potentially safe therapeutic intervention of HIV while minimizing toxicities.
Anti-HIV-1 activity of the Iboga alkaloid congene… [Planta Med. 2004] – PubMed – NCBI.